TNF alpha Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
AMC3012 | 500 µg | 594,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Reconstitute using 0.5 mL sterile distilled water. TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, ICC, N, WB |
Regulatory Status | RUO |
Immunogen | Recombinant mouse TNF-alpha produced in E. coli |
Host | Rb |
Genebank | TNF |
Isotype | Ig |
Crossreactivity | Hu, Ms |
Clonality | Pab |
Format | Lyophilized; PBS; , with 125mM trehalose and no preservative |
Concentration | 1 mg/mL |
Working Dilution | Neutralization (Assay-dependent), Western Blot (1:1,000), ELISA (Assay-dependent), Immunocytochem... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |