Granzyme B Monoclonal Antibody (GB11), PE-Texas Red

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Product Description

According to the literature this antibody recognizes the serine protease, granzyme B1. This enzyme is involved in apoptotic cell death. Granzyme B, as well as other enzymes contained in lytic granules, is released primarily by cytotoxic T lymphocytes (CTLs). In addition to immunostaining for flow cytometry, the GB11 mAb has been shown to be useful as an ELISA capture antibody. Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can a