CD81 Monoclonal Antibody (2F7), PE
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
HMCD8104 | 100 µg | 462,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymp
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Mouse CD81 (TAPA-1). from Mouse epithelial cell line PAM212 |
Host | Hm |
Clone Number | [2F7] |
Genebank | CD81 |
Isotype | IgG3 |
Crossreactivity | Hm, Ms |
Clonality | Mab |
Format | Liquid; PBS; , with <0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (0.1-0.2 µg / 1x10^6 cells) |
Purity | purified |
Conjugation | PE |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |