TNF alpha Monoclonal Antibody (E10041), Biotin

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Product Description

M3TNFABI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa. M3TNFABI targets TNF Alpha in ELISA and Western blot applications and shows reactivity with Canine, Feline, Human, Non-human primate, and Porcine samples. The MTNFAI antibody (clone E10043) has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody M3TNFABI (biotinylated conjugate of clone E10041). The M3TNFABI immunogen is recombinant human TNF alpha from Pichia pastoris. Lyophilized antibody should be reconstituted with 0.5 ml of distilled or deionized water to make a 0.1 mg/ml solution. TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis