Nanog Monoclonal Antibody (23D2-3C6), DyLight™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA1017D488 | 100 µL | 514,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-017-D488 has been successfully used in ICC/IF applications with human samples. MA1-017-D488 can be used for flow cytometry analysis of Nanog in human iPSCs. NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain. Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2. Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line. Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC |
Regulatory Status | RUO |
Immunogen | Full-length human recombinant protein expressed in bacteria |
Host | Ms |
Clone Number | [23D2-3C6] |
Genebank | NANOG |
Isotype | IgG1 |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; , with proprietary stabilizer and 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1:10-1:250), Flow Cytometry (1:100) |
Purity | Protein A |
Conjugation | DY 488 |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA1-017-D488 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |