PSD-95 Monoclonal Antibody (7E3-1B8)

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Product Description

MA1-046 detects post synaptic density 95 (PSD-95) from human, rat, xenopus laevis and mouse tissues. MA1-046 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, immunohistochemistry, flow cytometry and immunoprecipitation procedures. By Western blot, this antibody detects an ~95 kDa protein representing PSD-95 from rat brain extracts. Immunofluorescence staining of PSD-95 in rat hippocampal cells with MA1-046 yields a staining pattern coincident with NMDA receptor. In immunofluorescence staining, fixation with cold methanol is recommended. The MA1-046 immunogen is purified recombinant rat PSD-95. This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit. The antibody sold separately may have slightly different performance and may need to be further optimized for the best results. Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology