Lamin A Monoclonal Antibody (133A2)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA106101 | 100 µg | 584,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-06101 detects lamin A in human, mouse, rat, bovine and canine samples. MA1-06101 has sucessfully been used in immunocytochemistry, immunohistochemistry (paraffin), flow cytometry, and Western blotting procedures. The MA1-06101 immunogen is partially purified recombinant human lamin A. Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Partially purified recombinant human lamin A. |
Host | Ms |
Clone Number | [133A2] |
Genebank | LMNA |
Isotype | IgG3 |
Crossreactivity | Bo, Dg, Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.09% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Frozen) (1:100 - 1:200), Western Blot (1:100-1:1,000), Immunocytochemistry ... |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-06101 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |