Cytokeratin 10 Monoclonal Antibody (RKSE60)

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Product Description

MA1-06319 detects cytokeratin 10 in human, canine, rat, porcine, zebrafish and mouse samples. MA1-06319 has sucessfully been used in Western blotting, flow cytometry, immunocytochemistry, and immunohistochemistry. The MA1-06319 immmunogens are cytokeratins from the human epidermis. Store at 4ºC or -20ºC if preferred. Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (i.e., skin) and non-keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8. 5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.