PKP3 Monoclonal Antibody (23E3/4)

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Product Description

MA1-06511 detects plakophilin-3 in human, mouse, canine cells. MA1-06511 has sucessfully been used in Western blotting, immunoprecipitation, immunocytochemistry and immunohistochemistry procedures. By Western blot it detects a ~87 kDa band representing Plakophilin-3. The MA1-06511 immunogen is a synthetic peptide corresponding to residues F(570) T P Q S R R L R E L P L A A D A L T F(589) of human plakophilin-3. Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of ~87 kDa.