RTN1 Monoclonal Antibody (RNL-4)

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Product Description

MA1-06815 detects reticulon-1C(NSP-C) in human, porcine, and rat samples. MA1-06815 has sucessfully been used in flow cytometry, Western blotting, immunocytochemistry and immunohistochemistry procedures. By Western blot it detects a ~23 kDa band representing reticulon-1C. The MA1-06815 immunogen is a synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of reticulon-1C. Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showe