ITGB1 Monoclonal Antibody (2B1)

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Product Description

MA1-06906 detects integrin beta-1D in human, canine, porcine and mouse samples. MA1-06906 has sucessfully been used in immunocytochemistry, immunohistochemistry, and Western blotting procedures. The MA1-06906 immunogen is a synthetic peptide corresponding to the residues C Q(56) E N P I Y K S P I N N F K N P N Y G R K A G L(79) of the cytoplasmic domain of mouse integrin subunit b1D. Store at 4ºC or in small aliquots at -20ºC. ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell traffi