NUP62 Monoclonal Antibody (RL1)

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Product Description

MA1-071 detects nuclear pore-O-linked glycoprotein from rat, amphibian and yeast. MA1-071 has been successfully used in Western blot, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects up to eight different proteins from the nuclear pore complex (NPC) of approximately 210, 180, 145, 100, 63, 58, 54 and 45 kDa. Immunofluorescence staining of NPC O-linked glycoproteins with MA1-071 results in exclusive labeling of the NPC proteins on a wide variety of mammalian cells as well as S. cerevisiae and Xenopus. Labeling occurs exclusively at the NPC with most of the labeling at the cytoplasmic and nucleoplasmic margins. Microinjected MA1-071 inhibits both protein import and RNA export in Xenopus oocytes. The MA1-071 immunogen is pore complex-lamina fraction purified from rat liver nuclear envelopes. SDS3 is a subunit of the histone deacetylase.