OCT4 Monoclonal Antibody (9B7), DyLight™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA1104D488 | 100 µL | 504,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-104-D488 detects Oct4/Pou5F1 in human iPS samples. MA1-104-D488 has been successfully used in ICC/IF applications. POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC |
Regulatory Status | RUO |
Immunogen | Full length human recombinant protein of human POU5F1 produced in E.coli. |
Host | Ms |
Clone Number | [9B7] |
Genebank | POU5F1 |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; , with proprietary stabilizer and 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (5 µg/mL) |
Purity | Protein A |
Conjugation | DY 488 |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA1-104-D488 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |