Estrogen Receptor alpha Monoclonal Antibody (TE111.5D11)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA112692 | 100 µg | 876,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
A suggested positive control for this product is T47D cells. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, IP, N, WB |
Regulatory Status | RUO |
Immunogen | C-terminal fragment (aa 302-595) of human ER expressed in E coli. |
Host | Ms |
Clone Number | [TE111.5D11] |
Genebank | ESR1 |
Isotype | IgG1 |
Crossreactivity | Bo, Dg, Ck, Hm, Hu, Ms, Sh, Pg, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.08% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (2 µg/mL protein lysate), Western Blot (1-2 µg/mL), Gel Shift (Assay-dependen... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA1-12692 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |