ERK1 Monoclonal Antibody (12D11)

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Product Description

MA1-13041 detects ERK1 from human, mouse, and monkey samples. MA1-13041 does not cross react with ERK2. MA1-13041 has been successfully used in Western blot, ChIP, immunofluoresence, and immunohistochemistry procedures. By Western blot, this antibody detects a 44 kDa protein corresponding to ERK1. The MA1-13041 antigen is a recombinant protein corresponding to the full-length sequence of human ERK1. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and E