HIF-1 beta Monoclonal Antibody (H1beta234)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA116512 | 100 µL | 602,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: antigen standard for ARNT (transient overexpression lysate). HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the c
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Fusion protein containing residues 496-789 of human ARNT. |
Host | Ms |
Clone Number | [H1beta234] |
Genebank | ARNT |
Isotype | IgG1,k |
Crossreactivity | Bo, Ferret, Hu, Ms, Primate, Sh, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (Assay-Dependent), ChIP-Sequencing (Assay-Dependent), ChIP Assay (1:10-1:500)... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA1-16512 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |