c-Myc Monoclonal Antibody (9E11)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA116637 | 100 µL | 628,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: antigen standard for MYC (transient overexpression lysate), HL-60 cells or breast tumors, HL-60 whole cell lysate, human breast carcinoma whole cell lysate. The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-e
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, EL, FC, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide, conjugated to KLH, corresponding to residues A(408) E E Q K L I S E E D L(420) of human c-Myc. |
Host | Ms |
Clone Number | [9E11] |
Genebank | MYC |
Isotype | IgG2a,k |
Crossreactivity | Ck, Hu, Ms, Rt, Yeast |
Clonality | Mab |
Format | Liquid; PBS; , with 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Frozen) (1:100), Immunohistochemistry (Paraffin) (1:100), ELISA (1:100-1:2,... |
Purity | Protein A/G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-16637 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |