GAPDH Monoclonal Antibody (1D4)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA116757 | 100 µL | 638,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody is likely to react with most mammals. Suggested positive control: antigen standard for GAPDH (transient overexpression lysate). GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which ar
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Extensively purified pig GAPDH. |
Host | Ms |
Clone Number | [1D4] |
Genebank | GAPDH |
Isotype | IgM |
Crossreactivity | Avian, Bo, Dg, Ck, Drosophila, Ho, Ca, Hm, Hu, Marsupial, Ms, Primate, Sh, Pg, Rb, Rt, Zebrafish |
Clonality | Mab |
Format | Liquid; PBS; , with 50% glycerol and 5mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1:1,000), Immunocytochemistry (1:100), ChIP Assay (1:10 - 1:500), Immunoprecipitati... |
Purity | Affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-16757 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |