beta-2 Microglobulin Monoclonal Antibody (B2M-01)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA119141 | 100 µg | 592,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. It will not cross-react with mouse, rabbit, canine, chicken or bovine. Western Blot: Both reducing and non-reducing conditions. Non-reducing conditions preferred; RIA: Use at an assay dependent concentration. The dissociation constant of the antibody soluble beta2-microglobulin is 1.5 x 10^-8 mol/L as determined by competitive RIA. Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, a
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, ICC, IHC, IP, RIA, WB |
Regulatory Status | RUO |
Immunogen | Purified human beta-2 Microglobulin. |
Host | Ms |
Clone Number | [B2M-01] |
Genebank | B2M |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 15mM sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (1 µg/mL), Western Blot (2-4 µg/mL), Radioimmune assays (Assay-dependent), Immunoh... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA1-19141 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |