Cardiac Troponin I Monoclonal Antibody (M46)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA120122 | 200 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-20122 detects cardiac troponin 1 in human samples. Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Category | Antibody |
Supplier | ThermoFisher |
Application | AP, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Full length, human cardiac troponin 1 protein. |
Host | Ms |
Clone Number | [M46] |
Genebank | TNNI3 |
Isotype | IgG1 |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.09% sodium azide |
Concentration | 3.9 mg/mL |
Working Dilution | Western Blot (Assay-dependent), Affinity Purification (Assay-dependent), Immunoprecipitation (Ass... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA1-20122 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |