TLR4 Monoclonal Antibody (HTA125), PE
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA120237 | 50 Tests | 608,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-20237 detects TLR4 in human and Rhesus monkey samples. TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC |
Regulatory Status | RUO |
Immunogen | Human TLR4 expressed in Ba/F3 cell line. |
Host | Ms |
Clone Number | [HTA125] |
Genebank | TLR4 |
Isotype | IgG2a |
Crossreactivity | Dg, Gp, Hu, Primate, Pg, Rhesus Monkey |
Clonality | Mab |
Format | Liquid; PBS; , with 1% BSA, 5% sucrose and 0.09% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (Neat), Immunocytochemistry (Assay-dependent) |
Purity | Protein G |
Conjugation | PE |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA1-20237 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |