Myc Tag Monoclonal Antibody (Myc.A7)

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Product Description

MA1-21316 detects N-terminal or C-terminal Myc tagged fusion proteins. MA1-21316 may be stored at 4° C short term. Add 0.05% sodium azide if desired. For long term storage, store at -20° C, avoiding freeze/thaw cycles. Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.