TGF beta-1 Monoclonal Antibody (TB21)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA121595 | 100 µg | 654,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: Ovine ovarian tissue, breast cancer sections. By Western blot, this antibody detects detects dimeric (25 kDa) and monomeric (12.5 kDa) forms of TGF beta, under non-reducing and reducing conditions, respectively Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-a
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, IHC, N, WB |
Regulatory Status | RUO |
Immunogen | TGF-beta 1 from human platelets |
Host | Ms |
Clone Number | [TB21] |
Genebank | TGFB1 |
Isotype | IgG1 |
Crossreactivity | Bo, Hu, Mink, Ms, Mustelid, Sh, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.0, with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Neutralization (Assay-dependent), Immunohistochemistry (Frozen) (1:1,000), Western Blot (5-20 ng/... |
Purity | IgG fraction/Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-21595 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |