ATM Monoclonal Antibody (2C1)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA123152 | 100 µL | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: SK-N-SH, HeLa, HeLa nuclear extract. Predicted molecular weight of MA1-23152 is ~350kDa. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, EL, FC, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056. |
Host | Ms |
Clone Number | [2C1] |
Genebank | ATM |
Isotype | IgG1 |
Crossreactivity | Hu, Ms, Primate, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (5 ug/ml), Immunoprecipitation (1-10 ug/ml), Western Blot (1:500-... |
Purity | Affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-23152 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |