Estrogen Receptor beta Monoclonal Antibody (6A12)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA123221 | 100 µL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: Myc-DDK-tagged ESR2-transfected 293T, Recombinant fusion protein. Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate canc
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Amino acids 1-153 of human ER-ß expressed in E. coli. |
Host | Ms |
Clone Number | [6A12] |
Genebank | ESR2 |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1-5 µg/mL), ChIP Assay (Assay-dependent), Immunocytochemistry (Assay-dependent), Im... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-23221 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |