Phospho-beta Catenin (Ser33, Ser37) Monoclonal Antibody (BC-22)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA125084 | 50 µL | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: HEK-293 cells treated with proteasome inhibitor MG132. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tum
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide: DS(p)GIHS(p)GATTTAPS conjugated to KLH, corresponding to amino acids 32-45 of Human beta Catenin |
Host | Ms |
Clone Number | [BC-22] |
Genebank | CTNNB1 |
Isotype | IgG2b |
Crossreactivity | Ck, Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; 0.01M PBS; pH 7.4, with 15mM sodium azide |
Concentration | 2 mg/mL |
Working Dilution | ELISA (5-10 µg/mL), Western Blot (5-10 µg/mL) |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-25084 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |