Synaptotagmin 1 Monoclonal Antibody (ASV48)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA125482 | 100 µg | 656,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Possible positive controls for this product are rat brain tissue extract. Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Rat brain synaptic junction protein complexes. |
Host | Ms |
Clone Number | [ASV48] |
Genebank | SYT1 |
Isotype | IgG2b |
Crossreactivity | Bo, Ms, Primate, Rt, Shark |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with 0.1mM PMSF, 50% glycerol and 0.09% sodium azide |
Concentration | 1.0 mg/mL |
Working Dilution | Western Blot (1:1,000), Immunoprecipitation (Assay-dependent), Immunocytochemistry (1:500), Immun... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-25482 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |