HSC70 Monoclonal Antibody (1B5)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA126078 | 100 µg | 766,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: Bovine Hsc70 Protein and HeLa Heat Shocked Cell Lysate. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to reta
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Full length, native Hsc70 protein purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells. |
Host | Rt |
Clone Number | [1B5] |
Genebank | HSPA8 |
Isotype | IgG2a |
Crossreactivity | Dg, Gp, Hm, Hu, Many, Ms, Sh, Pg, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with 0.1mM PMSF, 50% glycerol and no preservative |
Concentration | 1 mg/mL |
Working Dilution | Immunohistochemistry (Assay-dependent), Western Blot (0.5 µg/mL), Immunoprecipitation (5 µg/mL), ... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-26078 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |