Collagen I Monoclonal Antibody (COL-1)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA126771 | 100 µL | 636,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The antibody is reactive with the native (helical) form of collagen type I in ELISA and dot blot. The product is not reactive when tested on thermally denatured molecules. In immunohistochemical staining of acetone-fixed and unfixed frozen sections, a strong staining of connective tissue fibers is seen. Using the dot blot and ELISA techniques, the antibody shows no cross-reactivity with collagen types, II, III, IV, V, VI, VII, IX, X and XI. The epitope recognized by the antibody is sensitive to routine formalin fixation and paraffin embedding.Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe tha
Category | Antibody |
Supplier | ThermoFisher |
Application | DB, EL, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Bovine skin collagen type I |
Host | Ms |
Clone Number | [COL-1] |
Genebank | COL1A1 |
Isotype | IgG1 |
Crossreactivity | Bo, Deer, Hu, Ms, Pg, Rb, Rt |
Clonality | Mab |
Format | Liquid; ascites; , with 15mM sodium azide |
Concentration | 7.4 mg/mL |
Working Dilution | Western Blot (Assay-dependent), Immunoprecipitation (Assay-dependent), Immunohistochemistry (Para... |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-26771 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |