CD18 Monoclonal Antibody (YFC118.3)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA133590 | 40 µg | 484,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: Tonsil. CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, IHC, IP |
Regulatory Status | RUO |
Immunogen | Human neutrophils |
Host | Rt |
Clone Number | [YFC118.3] |
Genebank | ITGB2 |
Isotype | IgG2b |
Crossreactivity | Dg, Gp, Hu |
Clonality | Mab |
Format | Liquid; PBS; , with 0.09% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (Assay-dependent), Flow Cytometry (1:50-1:100), Immunohistochemistry (Frozen)... |
Purity | IgG fraction |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-33590 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |