Calprotectin Monoclonal Antibody (MAC387)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA133972 | 100 µg | 776,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
For staining of paraffin sections, protein digestion pre-treatment (e.g. trypsin), 0.1% for 10 minutes or antigen retrieval using heat treatment is required. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | Human monocytes |
Host | Ms |
Clone Number | [MAC387] |
Genebank | S100A8 |
Isotype | IgG1 |
Crossreactivity | Baboon, Bo, Dg, Ho, Ca, Gt, Gp, Hu, Ms, Primate, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.09% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Flow Cytometry (1:50-1:100), Immunohistochemistry (Frozen) (1:100-1:200), Immunohistochemistry (P... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-33972 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |