CD25 Monoclonal Antibody (CD25-3G10), FITC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA135144 | 500 µL | 714,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | CD-25 receptor a-chain. |
Host | Ms |
Clone Number | [CD25-3G10] |
Genebank | IL2RA |
Isotype | IgG1 |
Crossreactivity | Hu, Ma, Ms, Rt |
Clonality | Mab |
Format | Liquid; PBS; , with BSA and 0.1% sodium azide |
Working Dilution | Flow Cytometry (5 µL / 1x10^6 cells) |
Purity | purified |
Conjugation | FITC |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA1-35144 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |