KappaB ras1 Monoclonal Antibody (184C278)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA141180 | 100 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: 293 whole cell lysate. KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic peptide corresponding to residues 96-113 of human kB-Ras1. |
| Host | Ms |
| Clone Number | [184C278] |
| Genebank | NKIRAS1 |
| Isotype | IgG1,k |
| Crossreactivity | Bo, Dg, Ho, Hu, Ms, Primate, Pg, Rt, Xenopus |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.2% gelatin and 0.05% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Western Blot (0.5-1 µg/mL) |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA1-41180 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
