Factor X/Xa Monoclonal Antibody (5051)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA143014 | 100 µg | 542,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody detects the heavy chain of bovine Factor X and Xa, BEGRck factor Xa. It will cross-react with human, rabbit, sheep, porcine and canine factor X. This antibody does not recognize murine Factor X via Western blot. Inhibitory properties: inhibitory in clotting assay (APTT and PT), partial calcium dependence. Dissociation Constant: Kd = 9X10^(-11)M. Purity >95% by SDS-PAGE. Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
Category | Antibody |
Supplier | ThermoFisher |
Application | AP, EL, RIA, WB |
Regulatory Status | RUO |
Immunogen | Purified bovine Factor X |
Host | Ms |
Clone Number | [5051] |
Genebank | F10 |
Isotype | IgG1 |
Crossreactivity | Bo, Dg, Hu, Sh, Pg, Rb |
Clonality | Mab |
Format | Liquid; 50% water; , with 50% glycerol and no preservative |
Concentration | 8.4 mg/mL |
Working Dilution | ELISA (Assay-Dependent), Affinity Purification (Assay-Dependent), Western Blot (5-10 µg/mL), Inhi... |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA1-43014 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |