Cdc20 Monoclonal Antibody (BA8)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| MA146040 | 100 µg | 600,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, FC, WB |
| Regulatory Status | RUO |
| Immunogen | Synthetic C terminal peptide (Xenopus laevis). BLAST 'FEVDPVTKKEKEKARSSKSIIHQSIR' |
| Host | Ms |
| Clone Number | [BA8] |
| Genebank | CDC20.S |
| Isotype | IgG2a |
| Crossreactivity | Xenopus |
| Clonality | Mab |
| Format | Liquid; PBS; , with 0.02% sodium azide |
| Concentration | 1.0 mg/mL |
| Working Dilution | ELISA (1:100-2,000), Western Blot (1:100-2,000), Flow Cytometry (1:10 - 1:1000) |
| Purity | Protein A/G |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: MA1-46040 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
