HSD3B1 Monoclonal Antibody (FDO66Q)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA146438 | 100 µL | 604,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Suggested positive control: human placental villi, antigen standard for HSD3B1 (transient overexpression lysate). Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | JEG Choriocarcinoma cells. |
Host | Ms |
Clone Number | [FDO66Q] |
Genebank | HSD3B1 |
Isotype | IgG1 |
Crossreactivity | Baboon, Bo, Gt, Hu, Ms, Primate, Sh, Pg, Rt |
Clonality | Mab |
Format | Liquid; tris glycine; , with 0.15M NaCl and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (10-20 µg/mL), Immunohistochemistry (Frozen) (10-20 µg/mL), Immunohistochemis... |
Purity | Protein G |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-46438 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |