SMN1/SMN2 Monoclonal Antibody (2B1)

* CHF, excl. 8.1% VAT and shipping costs

Product Description

MA1-5878 detects SMN in human, mouse and xenopus samples. MA1-5878 has been successfully used in Western blot, immunoprecipitation, immunofluorescence, immunohistochemistry (paraffin), flow cytometry, and ELISA procedures. MA1-5878 detects a band of approximately 42kDa. The MA1-5878 immunogen is purified recombinant His 6 tagged-SMN protein (human). The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.