Influenza A NP Monoclonal Antibody (D67J)

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Product Description

MA1-7057 detects the Influenza A virus. This antibody is specific for the nucleoprotein and is reactive with all A strains. MA1-7057 has been successfully used in immunofluorescence, immunohistochemistry, immunocytochemistry, and ELISA procedures. The MA1-7057 immunogen is Influenza A virus lysate. The nucleoprotein (NP) of Influenza A virus encapsidates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. "NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56" (Portela et al 2002).