Shiga toxin 2A Monoclonal Antibody (B19J)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA17101 | 1 mL | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-7101 detects the Verotoxin. This antibody is specific for Verotoxin II - A subunit (SLT-2a). MA1-7101 has been successfully used in ELISA procedures. The MA1-7101 immunogen is purified native toxoid. Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globot
Category | Antibody |
Supplier | ThermoFisher |
Application | EL |
Regulatory Status | RUO |
Immunogen | Purified native toxoid. |
Host | Ms |
Clone Number | [B19J] |
Isotype | IgG2 |
Crossreactivity | Bacteria |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with 0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | ELISA (1:20) |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: MA1-7101 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |