Hepatitis B Virus Core Antigen Monoclonal Antibody (10C6)

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Product Description

This antibody can be used for ELISA, Western blot, IHC, and Immunoprecipitation of in vitro-translated core and pre-core proteins. Strongly recognizes WHc (but not DHBc) in ELISA and immunoblot. Reacts with synthetic HBc peptides. Epitope: aa 138-145. The hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. Hepatitis B virus is spherical in shape with a diameter of 42nm. It contains a 27 nm partially double stranded DNA core enclosed within a lipoprotein coat. The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. The antigens in the outer surface are called as hepatitis B virus surface antigens. Core antigens are localized within the nuclei whereas the surface antigens are present in the cytoplasm of the infected cells. Antibodies to surface antigens appear in circulation at an early stage of infection whereas the antibodies to the core antigens are detected after several weeks. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries. Hepatitis B virus (HBV) belongs to the H