CD3 Monoclonal Antibody (RIV9)

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Product Description

MA1-7630 detects CD3 from human, rat and mouse samples. MA1-7630 has been successfully used in ELISA, flow cytometry, immunofluorescence, immunoprecipitation, and immunohistochemistry (frozen) procedures. The MA1-7630 immunogen is a CD3 protein. Store at 4ºC short term. For long term storage, store at -80ºC. The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells.