SIRP alpha Monoclonal Antibody (MRC OX-41), FITC
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA190103 | 100 µg | 606,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells. SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs. SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, RIA |
Regulatory Status | RUO |
Immunogen | Rat peritoneal macrophages |
Host | Ms |
Clone Number | [MRC OX-41] |
Genebank | SIRPA |
Isotype | IgG2a |
Crossreactivity | Rt |
Clonality | Mab |
Format | Liquid; PBS; , with 0.5% BSA and 0.02% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (Assay-dependent), Radioimmune assays (Assay-dependent), Immunocytochemistry (Assa... |
Purity | IgG fraction |
Conjugation | FITC |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
Disclaimer | Alternative CatNo: MA1-90103 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |