N-cadherin Monoclonal Antibody (CH-19)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA191128 | 100 µL | 672,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Recommended positive controls: MDBK. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, WB |
Regulatory Status | RUO |
Immunogen | synthetic peptide DYDYLNDWGPRFKKLADMYGGGDD conjugated to KLH, corresponding to amino acids 889-912 of Chicken N-Cadherin (cdh2). |
Host | Ms |
Clone Number | [CH-19] |
Genebank | CDH2 |
Isotype | IgG1 |
Crossreactivity | Bo, Dg, Ck, Ca, Gt, Gp, Hm, Hu, Ma, Ms, Sh, Pg, Rb, Rt, Reptile |
Clonality | Mab |
Format | Liquid; Ascites; , with 15mM sodium azide |
Concentration | 7.0 mg/mL |
Working Dilution | Immunocytochemistry (1:500), Western Blot (1:500), Immunohistochemistry (Paraffin) (1:500) |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: MA1-91128 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |