c-Myc Monoclonal Antibody (9E10), DyLight™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA1980D488 | 50 µL | 534,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA1-980-D488 detects c-myc protein and c-myc tagged proteins. MA1-980-D488 has been successfully used in fluorescent Western blot. DyLight 488 has an excitation/emission of 493/518 nm. The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-e
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, WB |
Regulatory Status | RUO |
Immunogen | Synthetic peptide A(408) E E Q K L I S E E D L L R K R R E Q L K H K L E Q L R N S C A(438) of human c-Myc. |
Host | Ms |
Clone Number | [9E10] |
Genebank | MYC |
Isotype | IgG1 |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; , with proprietary stabilizer and 0.02% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Western Blot (1:500-1:1,000), Immunocytochemistry (1:100) |
Purity | Protein A |
Conjugation | DY 488 |
Storage Conditions | 4° C, do not freeze |
Disclaimer | Alternative CatNo: MA1-980-D488 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |