GRP94 Monoclonal Antibody (9G10)

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Product Description

MA3-016 detects glucose regulated protein 94 kDa (GRP94) from human, rat, mouse, chick, hamster and bovine tissues. MA3-016 is also expected to react with GRP94 from Xenopus, human, canine, rabbit, non-human primate, canine, Drosophila, and ovine tissues. MA3-016 has been successfully used in Western blot, Immunohistochemistry (paraffin), immunocytochemistry, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects an ~108 kDa protein representing GRP94 in chick oviduct cytosol. The MA3-016 immunogen is chick oviduct GRP94. GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in mel