PDI Monoclonal Antibody (RL77)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA3018 | 100 µL | 666,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA3-018 detects protein disulphide-isomerase (PDI) from human, mouse, rat, porcine, xenopus liver tissues as well as hamster (CHO) cells and canine samples. MA3-018 has been successfully used in Western blot, immunofluorescence, immunohistochemical, flow cytometry, and immunoprecipitation procedures. By Western blot, this antibody detects a 59 kDa protein representing PDI from rat liver extract or a slightly higher protein at 61 kDa representing PDI from human liver extract. Immunohistochemical staining of PDI in rat intestine with MA3-018 yields a pattern consistent with cytoplasmic staining. In immunoprecipitation procedures MA3-018 has been shown to inhibit the activity of PDI in vitro. In immunohistochemistry procedures, formalin-fixed paraffin-embedded tissue sections are recommended. The MA3-018 antigen is purified rat PDI. Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations,
Category | Antibody |
Supplier | ThermoFisher |
Application | FC, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Purified rat PDI protein. |
Host | Ms |
Clone Number | [RL77] |
Genebank | P4HB |
Isotype | IgG2b |
Crossreactivity | Dg, Hm, Hu, Ms, Pg, Rt, Xenopus |
Clonality | Mab |
Format | Liquid; ascites; diluted in PBS, with 0.05% sodium azide |
Working Dilution | Immunohistochemistry (1:100), Immunoprecipitation (Assay-dependent), Immunocytochemistry (Assay-d... |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA3-018 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |