PDI Monoclonal Antibody (RL90), Alexa Fluor™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA3019A488 | 50 µL | 538,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA3019A488 detects protein disulphide-isomerase (PDI) from human, rat, porcine and mouse tissues as well as hamster cells. The MA3019A488 antigen is purified rat PDI. Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC |
Regulatory Status | RUO |
Immunogen | Purified rat PDI protein |
Host | Ms |
Clone Number | [RL90] |
Genebank | P4HB |
Isotype | IgG2a |
Crossreactivity | Hm, Hu, Ms, Pg, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 1mg/mL BSA and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1-10 µg/mL) |
Purity | Protein A |
Conjugation | Alexa Fluor 488 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: MA3-019-A488 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |