Acetylcholinesterase Monoclonal Antibody (ZR3)

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Product Description

MA3-041 contains 100 µL of in vitro produced, protein A purified IgG in PBS containing 1 mg/mL BSA and 0.05% sodium azide. MA3-041 detects acetylcholinesterase (AChE) from feline, human, rat, rabbit and guinea pig tissues. This antibody does not cross react with mouse, chicken, bovine, frog, or electric eel AChE. MA3-041 has been successfully used in immunohistochemistry and immunoprecipitation procedures. This antibody cannot be used in Western blot to detect AChE. Immunohistochemical staining of Ach in rat brain with MA3-041 results in staining of nerve fibers and terminals. MA3-041 reacts with both the soluble and membrane-associated AChE. The MA3-041 antigen is purified rat brain acetylcholinesterase. Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. The Protein is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic spec