CHRM2 Monoclonal Antibody (31-1D1)

* CHF, excl. 8.1% VAT and shipping costs

Product Description

MA3-044 detects muscarinic 2 acetylcholine receptor (m2AChR) from human, mouse, pig and rat tissues. This antibody does not detect mAChR from chicken tissues. MA3-044 is specific for the m2 mAChR subtype. MA3-044 has been successfully used in Western blot and immunoprecipitation protocols. MA3-044 is an ~52kDa protein; however, by Western blot this antibody may detect 60-80 kDa protein(s) (depending on the degree of glycosylation) representing the m2AChR from pig heart. The MA3-044 antigen is purified porcine cardiac m2 AChR. Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.