NPM1 Monoclonal Antibody (4TOU-1B2)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
MA3086 | 50 µL | 576,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
MA3-086 detects Nucleophosmin from human and mouse samples. MA3-086 has been successfully used in Western blot, immunofluorescence, Flow Cytometry, and ELISA applications. NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, NPM1 is believed to act as the interface for oligom
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, FC, ICC, WB |
Regulatory Status | RUO |
Host | Ms |
Clone Number | [4TOU-1B2] |
Genebank | NPM1 |
Isotype | IgG1,k |
Crossreactivity | Hu, Ms, Primate |
Clonality | Mab |
Format | Liquid; ascites; , with 0.05% sodium azide |
Working Dilution | Western Blot (1:500-1:1,000), Flow Cytometry (1:100-1:200), Immunocytochemistry (1:100-1:500), Ch... |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: MA3-086 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |